A new role for lactoferrin: DNA binding and transcription activation

Article Abstract:

Researchers suggests that the iron-binding protein, lactoferrin, found in milk modulates immune function. It is also seen that lactoferrin enters the nucleus of the cell from the serum where it binds the DNA, whose specific DNA sequences have been found. This direct transport function of lactoferrin, which remains to be confirmed in the whole cell, is unique. These results indicates the potential for explaining the role of the molecular basis of lactoferrin in the transfer of immunity from mother to child.

Analysis, DNA binding proteins, Lactoferrins

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Discovery of the hemochromatosis gene will require rethinking the regulation of iron metabolism

Article Abstract:

The discovery of the genetic defect responsible for hemochromatosis, a condition of excessive iron in the body, will increase the efforts of identifying the regulatory mechanism of iron. Genetic mutations of the major histocompatibility complex class-I-like protein were found in 83% of the patients with hemochromatosis in a 1996 study without illuminating the specifics of iron loading. A possible link between iron metabolism and immune regulation is emerging.

Physiological aspects, Genetic aspects, Iron in the body, Iron (Nutrient), Proteins, Hemochromatosis

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Vitamin D receptors: not just in the nucleus anymore

Article Abstract:

Calcitriol was the first biologically active form of vitamin D discovered, and it is assumed to act through a vitamin D receptor (VDR) in the nucleus of the cell. Recent research has found firm evidence that a VDR exists in the cell membrane, distinct from the nuclear VDR. Whether the function of the membrane VDR is critical to the function of the nuclear VDR remains to be determined.

Research, Vitamin D, Calcitriol

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