Developmental stages and energy restriction affect cellular oncogene expression in tissues of female rats
Article Abstract:
A study was done on the effects of developmental stages and energy restriction on the cellular oncogene expression in mammary tissues of female rats. Measurement of c-Ha-ras and c-fos RNA transcripts during pregnancy and lactation show that developmental stages and energy restriction affect cellular oncogene mRNA levels with tissue-specific patterns. c-Ha-ras and c-fos levels peaked at nine weeks in rat mammary tissue and estrogen was implicated to be responsible for the surge in the transcript values.
Publication Name: The Journal of Nutrition
Subject: Food/cooking/nutrition
ISSN: 0022-3166
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Age, dietary selenium and quantity of 7, 12-dimethylbenz(a)anthracene influence the in vivo occurrence of rat mammary adducts
Article Abstract:
A study was done on the effects of age, dietary selenium and quantity of 7,12-dimethylbenz(a)anthracene (DMBA) on the in vivo occurrence of rat mammary adducts. It was shown that DMBA-DNA binding increased with age of the rats and decreased with an increase in concentration of administered carcinogen. Furthermore, it was shown that selenium inhibits DMBA metabolism at a dosage of five to 50 mg/kg body weight.
Publication Name: The Journal of Nutrition
Subject: Food/cooking/nutrition
ISSN: 0022-3166
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Nuclear zinc uptake and interactions and metallothionein gene expression are influenced by dietary zinc in rats
- Abstracts: Postnatal selenium repletion protects lungs of neonatal rats from hyperoxia. Cephaloridine nephrotoxicity is potentiated by selenium deficiency but not copper deficiency in rats
- Abstracts: Dose-response relationships between dietary (n-3) fatty acids and plasma and tissue lipids, steroid excretion and urinary malondialdehyde in rats
- Abstracts: Pyridoxine-5'-beta-D-glucoside affects the metabolic utilization of pyridoxine in rats. In vivo folate kinetics during chronic supplementation of human subjects with deuterium-labeled folic acid