Dietary fat type and cholesterol quantity interact to affect cholesterol metabolism in guinea pigs

Article Abstract:

Effects of dietary fat types and cholesterol quantity on guinea pig cholesterol metabolism are evaluated. Dietary fat type does not affect the increased plasma cholesterol, which is due to increased dietary cholesterol. Saturated fats increased, while polyunsaturated fats decreased plasma HDL. Pharmacologic levels of dietary cholesterol also increased plasma HDL levels. Increased dietary cholesterol increased hepatic free and esterified cholesterol levels. However, lard-fed guinea pigs accumulated the least amount. Hepatic 3-hydroxy-3-methylglutaryl coenzyme A reductase,which is used in cholesterol synthesis, was decreased by dietary cholesterol.

Research, Dietary fat, Cholesterol metabolism

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Modification of plasma and hepatic lipids of guinea pigs by feeding high oleic acid pork compared with regular pork

Article Abstract:

Guinea pigs were fed pork with a high oleic acid to determine if monounsaturated fatty acids had beneficial effects. Serum cholesterol and liporotein profiles and liver tissue studies were analyzed. Results showed that dietary fat intake did not affect high density lipoprotein levels in guinea pigs although receptor number and binding were enhanced. Similarly, low density lipoproteins remained constant with low fat, high oleic acid intake. A 15% fat diet increased hepatic cholesterol levels in olive oil against lard-fed animals. These findings may have beneficial effects when applied to human diets.

Physiological aspects, Lipoproteins, Oleic acid

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