Interaction of carnitine and propionate with pyruvate oxidation by hepatocytes from clofibrate-treated rats: importance of Coenzyme A availability
Article Abstract:
Propionate disrupts normal liver function after the accumulation of acylcoenzyme As. Clofibrate can regulate the toxic effects of propionate in the liver by increasing the total amount of coenzyme A. Hepatocytes from clofibrate-treated rats were isolated and used to study its effect on the interactions of propionate and carnitine with pyruvate oxidation. Propionate exhibited a decreased inhibitory effect. The antitoxic effects of carnitine did not increase because carnitine also induced a decrease in total coenzyme A content.
Publication Name: The Journal of Nutrition
Subject: Food/cooking/nutrition
ISSN: 0022-3166
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
L-carnitine administration and withdrawal affect plasma and hepatic carnitine concentrations, plasma lipid and lipoprotein composition, and in vitro hepatic lipogenesis from labeled mevalonate and oleate in normal rabbits
Article Abstract:
The effects of L-carnitine administration and withdrawal on lipid and lipoprotein metabolism were investigated. The results showed that carnitine administration promotes increases in plasma and hepatic carnitine levels. However, upon withdrawal, only the plasma levels returned rapidly to normal. In addition, withdrawal of carnitine led to reductions in plasma total cholesterol and VLDL cholesterol, and increases in IDL, LDL and HDL proteins. Moreover, carnitine withdrawal also altered hepatic lipid synthesis profiles.
Publication Name: The Journal of Nutrition
Subject: Food/cooking/nutrition
ISSN: 0022-3166
Year: 1992
User Contributions:
Comment about this article or add new information about this topic:
Intraruminal infusion of propionate alters feeding behavior and decreases energy intake of lactating dairy cows
Article Abstract:
dlact
Publication Name: The Journal of Nutrition
Subject: Food/cooking/nutrition
ISSN: 0022-3166
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Interaction of the hemochromatosis gene product HFE with transferrin receptor modulates cellular iron metabolism
- Abstracts: Secretion of vitamin A and retinol-binding protein into plasma is depressed in rats by N-(4-hydroxyphenyl)retinamide (fenretinide)
- Abstracts: Introduction. (n-3) fatty acids, tissue lipid peroxidation and tocopherol status. Lung eicosanoid synthesis is affected by age, dietary fat and vitamin E
- Abstracts: The use of avian epiphyseal chondrocytes for in vitro studies of skeletal metabolism. In vitro systems for the analysis of the development of adipose tissue in domestic animals
- Abstracts: Response of somatomedins (IGF-I and IGF-II) in lactating cows to variations in dietary energy and protein and treatment with recombinant n-methionyl bovine somatotropin