Methionine intake in rainbow trout (Oncorhynchus mykiss), relationship to cataract formation and the metabolism of methionine

Article Abstract:

Studies were made on the effects of methionine on vision of rainbow trout, which were fed diets with graded amounts of methionine. Measurements show that the minimum daily methionine requirement to sustain growth is only 0.76% of the total diet or 1.9% of protein needs. However, the fish need a higher methionine intake of 0.96% of total diet to prevent bilateral cataracts. An intake of 0.36% cystine lowers the requirement to 0.60%. A greater intake enhances transulfuration, as evidenced by higher liver and plasma taurine, and stimulates ornithine decarboxylase activity.

Cataract, Cataracts, Rainbow trout, Methionine, Amino acid metabolism

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Thiazolidine-4-carboxylate and 2-phenylthiazolidine-4-carboxylate are active as cysteine precursors but have no effect on growth of a methionine-dependent tumor in rats

Article Abstract:

The efficacy of thiazolidine-4-carboxylate and 2-phenylthiazolidine-4-carboxylate as cysteine precursors and their effect on rhabdomyosarcoma growth in rats were examined by dietary alterations and supplementations in normal and tumor-bearing rats. Replacement of dietary methionine or cysteine with one of the thiazolidine compounds did not affect the serum sulfur amino acid and albumin levels. Food intake and feed conversion ratio were also not affected. Similarly, no effect on tumor growth was observed.

Antineoplastic agents, Amino acids, Rhabdomyosarcoma

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Prolonged acetaminophen ingestion by mice fed a methionine-limited diet does not affect iron-induced liver lipid peroxidation or S-adenosylmethionine

Article Abstract:

A study was done to determine whether chronic acetaminophen (ACAP)-induced glutathione depletion would increase mice susceptibility to iron-induced liver lipid peroxidation. Results show that chronic ACAP does not increase the susceptibility of mice to liver lipid peroxidation. However, it causes a significant decrease in nonprotein sulfhydryl in mice fed with 0.25% methionine diets and those fed with 0.5% methionine accompanied by intraperitoneal iron administration.

Lipids, Oxidation-reduction reaction, Oxidation-reduction reactions, Acetaminophen, Glutathione

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