In vitro activity of temafloxacin against gram-negative bacteria: an overview

Article Abstract:

The effectiveness of the antibiotic temafloxacin to inhibit growth of various bacteria in the group known as gram-negative was examined. Temafloxacin was effective in inhibiting the following bacteria which cause respiratory infections: Hemophilus influenzae, Moraxella catarrhalis, Neisseria meningitidis, Bordetella pertussis, and Legionella pneumophila. Temafloxacin was also shown to inhibit bacteria, such as Neisseria gonorrhoea and Chlamydia trachomatis, which cause sexually-transmitted diseases. Temafloxacin also inhibited gram-negative bacteria, such as Escherichia coli, species of Salmonella, Shigella, and Vibrio, Helicobacter pylori, and Campylobacter jejuni, which cause infections of the gastrointestinal tract. However, larger doses of temafloxacin were needed to treat these organisms. These doses would easily be achieved when given the normal oral dose of temafloxacin. Therefore, temafloxacin appears to be an effective antibiotic against a number of gram-negative bacteria causing a variety of diseases. (Consumer Summary produced by Reliance Medical Information, Inc.)

Gram-negative bacteria

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In vitro activity of temafloxacin against gram-positive cocci including methicillin-resistant Staphylococcus aureus

Article Abstract:

Fluoroquinolones are a new type of antibiotic that was introduced in the mid1980s. The effectiveness of three types of fluoroquinolones - temafloxacin, ciprofloxacin and ofloxacin - in causing inhibition of growth of gram-positive bacteria was reviewed. The gram-positive organisms tested included Staphylococcus aureus, Streptococci pneumoniae, and Streptococci pyogenes. All these bacteria cause respiratory infections. Certain types of Staphylococcus aureus are resistant to the antibiotic methicillin, which has previously been used to treat infections caused by this organism. The results showed that these bacteria were killed by the fluoroquinolones. The effectiveness of temafloxacin was the same or slightly better than that of ciprofloxacin. Both were more effective than ofloxacin. Higher levels of temafloxacin were found in the blood. Therefore, it is felt that temafloxacin would be a more effective agent in treating infections caused by gram positive organisms. (Consumer Summary produced by Reliance Medical Information, Inc.)

Gram-positive bacteria

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In vitro activity of temafloxacin against pathogens causing sexually transmitted diseases

Article Abstract:

Problems exist in the treatment of sexually transmitted diseases caused by certain bacteria, including Neisseria gonorrhoea, Chlamydia trachomatis, Mycoplasma hominis and Ureaplasma urealyticum. Strains of bacteria have evolved that are resistant to antibiotics, such as penicillin, which have traditionally been used for the treatment of these infections. Other types of antibiotics may be effective, but can cause side effects. A new type of antibiotic, the fluoroquinolones, has been shown to be effective in the treatment of various bacterial infections, including those that are sexually transmitted. The levels of temafloxacin, one of the most effective fluoroquinolones, achieved in the blood after oral doses are greater than the levels required to kill these bacteria. Therefore, temafloxacin can be used to effectively treat bacterial sexually transmitted diseases. (Consumer Summary produced by Reliance Medical Information, Inc.)

Sexually transmitted diseases, Drug therapy

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