90K protein: a new predictor marker of disease progression in human immunodeficiency virus infection

Article Abstract:

Levels of 90K protein may predict disease progression in HIV patients. 90K protein is a tumor-associated protein in cancer patients that has been found to be a marker of HIV infection. HIV infection is characterized by the depletion of certain white blood cells, CD4 T-cells, and patients are considered to have AIDS when their CD4 T-cell count drops below a specified level. 90K levels were measured over a four-year period in 49 initially asymptomatic HIV-positive patients. Ten progressed to AIDS-related complex (ARC), eight progressed to AIDS and the other 31 had not progressed and remained symptom-free. At both the first and last visits, patients who eventually developed AIDS or ARC had higher levels of 90K than patients who remained asymptomatic, and asymptomatic patients had higher levels than HIV-negative blood donors. 90K levels steadily increased in most patients who progressed. Furthermore, 90K levels rose earlier in the course of disease than levels of CD4 T-cells dropped.

Usage, Tumor proteins

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The 90K tumor-associated antigen and clinical progression in human immunodeficiency virus infection

Article Abstract:

Increased blood levels of a protein called 90K may signal a worse prognosis in HIV-infected people. 90K is a naturally-occurring protein in the human body that is often elevated in conditions such as cancer, hepatitis and pregnancy. Researchers followed 488 HIV-positive injection drug users and 173 HIV-negative injection drug users. All participants were examined every three months at which time blood samples were analyzed for CD4 T cell counts and 90K levels. Sixty-one of the HIV-positive drug users developed AIDS during the study. Thirty-nine percent of those with the highest 90K levels progressed to AIDS compared to 7% of those with the lowest levels. Those with a low T cell count and viral p24 antigen in their blood had the highest 90K levels. Those with high 90K levels were more likely to develop AIDS and had a shorter survival.

Measurement, Development and progression, Tumor antigens

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Survival prognosis of HIV-infected patients

Article Abstract:

The survival of HIV patients is dependent upon their immune status, as measured by CD4 T-lymphocyte levels, and the development of an AIDS-indicating condition. HIV, or human immunodeficiency virus, is the virus that causes AIDS. T-lymphocytes are a component of the body's immune system. Low T-cell counts indicate a dysfunctional immune system. Of 839 HIV-infected patients treated at a health clinic, 29.7% had AIDS and 18.6% had an AIDS-defining disease. Those who had the highest risk of death were those with low CD4 T-lymphocyte counts and AIDS-defining illnesses, including wasting syndrome, Pneumocystis carinii pneumonia, lymphoma, Kaposi's sarcoma and candidiasis. Treatment with zidovudine significantly prolonged survival, even in patients with low CD4 T-lymphocytes.

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