A 79-year-old woman with anorexia, weight loss, and diarrhea after treatment for celiac disease
Article Abstract:
People with long-standing celiac disease who experience a relapse should have intestinal biopsies to detect T cell lymphoma. Celiac disease is characterized by intestinal malabsorption. A 79-year-old woman with celiac disease of 10 years' duration was hospitalized with lack of appetite, weight loss and diarrhea. Prednisone treatment resolved some of her symptoms but fiberoptic endoscopy revealed many large ulcers in her stomach. Biopsy samples of tissue around the ulcers were found to contain malignant tumor cells, which were identified as T cells. Two days later, exploratory laparoscopy revealed a large white mass in the stomach and small nodules in the small intestine. She eventually developed congestive heart failure and died. People with long-standing celiac disease are known to have a high risk of lymphoma.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1996
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A 39-year-old woman with pernicious anemia and a gastric mass
Article Abstract:
A 39-year-old woman was admitted to a hospital for evaluation of a mass in her stomach after a long history of abdominal pain. The mass had been found by a CT scan three months before. The mass was consistent with carcinoid tumor, which is a gastrointestinal tumor. A biopsy confirmed the diagnosis. This patient had pernicious anemia, which has often been linked to carcinoid tumor. The mechanism probably involves a cell proliferation induced by high levels of gastrin. Patients with pernicious anemia do not produce normal levels of stomach acid, which regulates the amount of gastrin secreted.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
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A 59-year-old man with anorexia, weight loss, and a mediastinal mass
Article Abstract:
A 59-year-old man was admitted to a hospital with anorexia, fatigue, and weight loss. His symptoms had begun two years earlier. Chest X-rays and a CT scan showed a mass in between his lungs. Biopsy revealed that the mass was fatty tissue, leading his doctors to suspect sarcoidosis. However, microscopic examination of biopsy tissue from his small intestine revealed infection with the bacterium that causes Whipple's disease. The polymerase chain reaction was used to confirm the presence of the bacterium.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
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