A comparison of aspirin plus tirofiban with aspirin plus heparin for unstable angina

Article Abstract:

Tirofiban and aspirin may be superior to heparin and aspirin in preventing heart attack and death in patients hospitalized for unstable angina. Patients with an unstable pattern of chest pain may be at increased risk of heart attack. Researchers assigned 3,232 patients to treatment with either tirofiban and aspirin or heparin and aspirin for 48 hours. The rate of death or heart attack immediately after treatment was 32% lower in patients who received tirofiban and aspirin. Tirofiban may be useful in short-term and long-term prevention of heart attack and cardiac death.

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Inhibition of the platelet glycoprotein IIb/IIIa receptor with tirofiban in unstable angina and non-Q-wave myocardial infarction

Article Abstract:

The addition of tirofiban to a regimen of heparin and aspirin may reduce the incidence of heart attack and death in patients with unstable angina or recent heart attack. Tirofiban inhibits the clotting activity of blood platelets. Researchers assigned 1,915 patients to therapy with heparin and aspirin and, in some patients, tirofiban prior to blood vessel imaging or angioplasty. Tirofiban plus heparin and aspirin decreased the rate of heart attack and death by 32% in the first seven days, compared to the rate in patients taking heparin and aspirin alone.

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Platelet glycoprotein IIb/IIIa receptor blockade in unstable coronary disease

Article Abstract:

Early positive results from studies of the short-term use of tirofiban for unstable angina and heart attack raise questions about the proper place of platelet-receptor-blocking drugs in acute coronary disease. Tirofiban impedes the activity of blood platelets, which contribute to clot formation in the arteries of the heart. Short-term use of this drug appears to reduce the risk of heart attack and death in patients with unstable coronary disease. Whether this drug may prevent or delay heart surgery, or provide long-term benefit, is not yet clear.

Health aspects, Editorial

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