A comparison of continuous infusion of alteplase with double-bolus administration for acute myocardial infarction

Article Abstract:

Alteplase given continuously over a 90-minute period appears to be safer for patients with a recent heart attack than two alteplase injections given within 30 minutes. Death and stroke rates were compared among 7,169 patients with recent heart attacks given alteplase using one of these two methods. Investigators terminated the study because death rates 30 days after treatment were relatively much higher for patients given the double injections than those given 90-minute infusions. Of the patients given double injections of alteplase, 7.98% died within 30 days of treatment and 1.92% had a stroke.

Dosage and administration, Tissue plasminogen activator, Infusion therapy

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Angiotensin-receptor blockade in acute myocardial infarction -- a matter of dose

Article Abstract:

The drug valsartan may be as effective as captopril for treating patients who have had a heart attack and also have heart failure, according to a study published in 2003. Other studies have not found the two drugs to be equivalent, but they used smaller doses of valsartan. Valsartan is more expensive than captopril, but doctors now have an alternative drug they can use for patients who cannot take captopril for whatever reason.

Editorial, Angiotensin II receptor blockers, Captopril

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A dose-dependent increase in mortality with vesnarinone among patients with severe heart failure

Article Abstract:

The drug vesnarinone appears to increase mortality rates in patients with heart failure. In a study of 3,833 patients with severe heart failure who took vesnarinone or a placebo, 23% of those taking the drug died compared to 19% in the placebo group. The increased mortality rate was primarily due to sudden death from arrhythmia. The drug improved quality of life but was also linked to low white blood cell levels.

Patient outcomes, Mortality, Complications and side effects, Cardiac patients, Cardiotonic agents

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