A glycemic threshold for diabetic complications?

Article Abstract:

The use of ACE inhibitors in patients with insulin-dependent diabetes and microalbuminuria may be more effective in preventing diabetic complications than excessive efforts to control blood glucose. Microalbuminuria is a condition of increased urinary excretion of albumin that may lead to kidney disease. High blood pressure in the kidney appears to be necessary for the development of kidney disease in diabetic patients with high blood sugar. A 1995 study found that the risk of microalbuminuria is very small if the patient's glycosylated hemoglobin values - a way of measuring blood sugar - are maintained at 8%. But the Diabetes Control and Complications Trial showed that many patients with glycosylated hemoglobin values of 7% still developed microalbuminuria. Many of these patients also experienced severe hypoglycemia from their intensive insulin treatment. ACE inhibitors alone can reduce the risk of kidney disease in diabetic patients with microalbuminuria by more than 60%.

Care and treatment, Editorial, Prevention, Diabetic nephropathies, Hyperglycemia, Albuminuria

---

Familial clustering of cardiovascular disease in patients with insulin-dependent diabetes and nephropathy

Article Abstract:

Patients with insulin-dependent diabetes mellitus whose parents have cardiovascular disease may have a higher risk of developing kidney disease than those whose parents do not. Sixty-one patients under 65 years-of-age with insulin-independent diabetes and kidney disease were compared to 61 insulin-dependent diabetics without kidney disease. Medical histories were obtained for 117 parents of patients with kidney disease and 116 parents of patients without kidney disease. Sixty-two percent of the parents of patients with kidney disease had died compared to only 32% of the parents of patients without kidney disease. Forty percent of the parents of patients with kidney disease died from cardiovascular disease compared to 22% of the parents of patients without kidney disease. Of the parents who were still alive, 16% percent of the parents of patients with kidney disease had cardiovascular disease compared to 10% of the parents of patients without kidney disease.

Type 1 diabetes, Kidney diseases

---

Cardiovascular disease

Article Abstract:

Gene mutations involved in cardiovascular disease are described. Topics include mutations that affect blood pressure and cholesterol levels, coronary artery disease, hypertension, thrombosis and hemostasis, hypertrophic cardiomyopathy, cardiac arrhythmias, gene polymorphisms, and gene-expression profiling. There are no genetic tests for cardiovascular disease.

Similar abstracts:

• Abstracts: Changes in physician practice for the prevention of cardiovascular disease. part 2 Effects of simvastatin and cholestyramine in familial and nonfamilial hypercholesterolemia
• Abstracts: The latest report from Finland: a lesson in expectations. Severe mental illness and risk of cardiovascular disease
• Abstracts: Hepatitis B prevalence in an unregistered prenatal population: implications for neonatal therapy. Injection Practices Among Nurses--Valcea, Romania, 1998
• Abstracts: Immune globulin to prevent nosocomial infections. Cicatricial pemphigoid. Manipulating the immune system with immune globulin
• Abstracts: Public policy for sound hearts. A van full of bikes. Health through exercise - a law of nature

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.