A ligand-receptor fusion of growth hormone forms a dimer and is a potent long-acting agonist
Article Abstract:
The biological actions of a ligand-receptor fusion of growth hormone and the extracellular domain of its receptor are analyzed. The studies have shown that a ligand-receptor fusion of cytokine to its extracellular receptor has generated a potent, long-acting agonist with exceptionally slow absorption and elimination.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
Efficacy of short-term monotherapy with maraviroc, a new CCR5 antagonist, in patients infected with HIV-1
Article Abstract:
The efficacy and safety of 10-d monotherapy with the orally administered CCR5 antagonist maraviroc in 63 HIV-1 positive individuals prescreened for the absence of CXCR4-using virus is assessed. Results provide a proof of concept that CCR5 is a viable antiretroviral therapeutic approach.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
HIV-1 and HAART: a time to cure, a time to kill
Article Abstract:
HIV-1, long-lived, latently infected cells that evade immune detection, and highly active antiretroviral therapy, are discussed. Two clinical studies have shown failure of conventional anti-retroviral therapy to eradicate HIV, and it may take 10-60 years to eliminate HIV.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: The efficacy of caries detection using three intraoral films under different processing conditions. Success of an alternative for interim management of irreversible pulpitis
- Abstracts: Perceptions of desirable tooth color among parents, dentists and children. Rosy cheeked
- Abstracts: A reflective account of a trip to escort a sick patient overseas. Diagnosing, treating and managing carcinoid tumors
- Abstracts: A cost-effectiveness evaluation of preoperative type-and-screen testing for vaginal hysterectomy. Expression of cyclooxygenase-2 in advanced stage ovarian serous carcinoma: Correlation with tumor cell proliferation, apoptosis, angiogenesis, and survival
- Abstracts: The vaginal introitus: a novel site for Chlamydia trachomatis testing in women. Insight into the treatment of vulvar pain: A survey of clinicians