A novel genotype encoding a single amino acid insertion and five other substitutions between residues 64 and 74 of the HIV-1 reverse transcriptase confers high-level cross-resistance to nucleoside transcriptase inhibitors
Article Abstract:
A mutation consisting of an aspartate codon insertion between positions 69 and 70 in the beta3-beta4 connecting loop of the reverse transcriptase fingers subdomain leads to strong drug resistance by HIV. Resistance to nucleoside reverse transcriptase inhibitors is most likely but the mutation can co-exist with mutations conferring resistance to other AIDS drugs.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 1999
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Nucleoside reverse transcriptase inhibitor resistance
Article Abstract:
Resistance to nucleoside reverse transcriptase inhibitors is the most actively studied form of HIV drug resistance because these drugs were the first to be used to treat HIV infection. They include zidovudine, lamivudine, stavudine, didanosine, zalcitabine, and abacavir.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Antiviral resistance of biologic HIV-2 clones obtained from individuals on nucleoside reverse transcriptase inhibitor therapy
Article Abstract:
HIV-2 can become resistant to AIDS drugs through gene mutations. Some of the mutations correspond to gene mutations seen in HIV-1.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
User Contributions:
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