A phase II trial of dual protease inhibitor therapy: amprenavir in combination with indinavir, nelfinavir, or saquinavir
Article Abstract:
Treating HIV infection with two protease inhibitors simultaneously may be beneficial, according to a study of 33 patients. However, four patients who did not respond to this treatment were found to have protease-resistant virus even though none had protease-resistant virus when they began treatment.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Comparison of two indinavir/ritonavir in the treatment of HIV-infected individuals
Article Abstract:
The two-ritonavir/indinavir regimens in the treatment of HIV-infected individuals are compared. Both regimens exhibited similar tolerability and response rates and high toxicity with a low response suggests that the optimum IDV/RTV combination would include an RTV dose<400mg and an IDV dose <800mg in the population.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2004
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Phase I/II study of the toxicity, pharmacokinetics, and activity of the HIV protease inhibitor SC-52151
Article Abstract:
Two fat-soluble formulations of the HIV protease inhibitor SC-52151 appear to be well-tolerated. This drug is not soluble in water so two other formulations have been developed: an ethanol-based elixir and a self-emulsifying drug delivery system (SEDDS). Forty-nine HIV-infected patients were randomly assigned to take 2,250 milligrams of either formulation two or three times a day. The SEDDS formulation resulted in higher drug concentrations as did twice daily administration. There were few serious side effects but the drug did not substantially affect HIV RNA levels.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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