Virologic and immunologic effect of antiretroviral therapy on HIV-1 in gut-associated lymphoid tissue
Article Abstract:
Antiretroviral therapy inhibited HIV reproduction in gut-associated lymphoid tissue (GALT), according to a study of 8 HIV patients. GALT contains about half of the body's white blood cells and appears to be a preferred site of viral reproduction.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Open-label phase II trial of amprenavir, abacavir, and fixed-dose zidovudine/lamivudine in newly and chronically HIV-1-infected patients
Article Abstract:
The combination of amprenavir, abacavir, zidovudine, and lamivudine twice a day can suppress HIV and boost CD4+ T cell levels. This was the conclusion of a study of 27 newly diagnosed HIV patients and 12 chronically infected patients.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2001
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Quantifying residual HIV-1 replication in patients receiving combination antiretroviral therapy
Article Abstract:
Highly active antiretroviral therapy may not completely suppress HIV in HIV patients who take the drugs. This combination therapy usually includes protease inhibitors, which can reduce blood levels of the virus to undetectable levels. However, the virus can still hide out inside immune system cells. Researchers took blood samples from eight patients on combination therapy who had undetectable viral levels and found that two patients had evidence of continuing virus evolution. This means that combination therapy may not suppress HIV reproduction in all patients.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
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