A randomized study of outpatient treatment with ceftriaxone for selected febrile children with sickle cell disease

Article Abstract:

Ceftriaxone may be an effective and safe treatment for at least half the episodes of fever that occur in children with sickle cell anemia who are treated as outpatients. Sickle cell anemia is a genetic disorder characterized by sickle-shaped red blood cells. Among 86 sickle cell anemia patients between six months and 12 years old who had a temperature above 38.5 deg C, 44 were treated as outpatients and 42 were treated as inpatients. All the children were initially treated with 50 milligrams of intravenous (IV) ceftriaxone per kilogram of body weight. Outpatients returned to the hospital for a second dosage of ceftriaxone, and inpatients usually received a second dosage of ceftriaxone in the hospital. Eleven outpatients were hospitalized within two weeks of their initial treatment with ceftriaxone, compared with one inpatient. Treatment as an outpatient reduced the cost of medical care by $1,195 per episode of fever.

Health aspects, Sickle cell anemia in children, Sickle cell anemia, Fever in children, Childhood fever, Ceftriaxone

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Long-term intellectual and behavioral outcomes of children with febrile convulsions

Article Abstract:

Children who have febrile convulsions appear to have little risk for mental retardation or behavioral disorders. A febrile convulsion is a seizure accompanied by fever. Researchers analyzed the intellectual and behavioral outcomes of 14,676 10-year-old children, including 381 who had had febrile convulsions as infants. The children who had had febrile convulsions in infancy performed just as well as the other children on most of the tests and evaluations. They were more likely to be in special schools, but the number of children in such programs was still very small.

Evaluation, Prognosis, Child development, Epilepsy in children, Pediatric epilepsy

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A comparision of high-dose and standard-dose epinephirne in children with cardiac arrest

Article Abstract:

A study is conducted to find any benefits of high-dose epinephirine rescue therapy for in-hospital cardiac arrest in children. High dose therapy may be worse than standard dose therapy.

United States, Dosage and administration, Epinephrine, CPR (First aid), Cardiac arrest, Cardiopulmonary resuscitation

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