Mechanisms of Virologic Failure in Previously Untreated HIV-lnfected Patients From a Trial of Induction-Maintenance Therapy
Article Abstract:
The failure of AIDS drugs to control HIV infection may be caused by non-compliance or low blood levels of the drug. This was the conclusion of researchers who analyzed various factors among 58 HIV patients who failed treatment. A viral gene mutation for drug resistance was found in many of these patients, but it was also found in many patients whose infection was controlled by the drugs. In many patients, drug levels in the blood were too low to be effective and many patients did not take all their doses.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
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Efficacy and tolerability of stavudine plus lamivudine in treatment-naive and treatment-experienced patients with HIV-1 infection
Article Abstract:
The AIDS drugs stamuvidine and lamivudine appear to be effective when used together. Researchers evaluated 83 HIV patients who began taking the drugs. Forty-two had never been treated and 41 had taken other AIDS drugs. The drugs lowered blood levels of the virus and increased CD4+ T cell counts. The patients who had never been treated were more likely to benefit. Seventeen percent of the 83 patients developed side effects and two stopped taking the drugs for that reason.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1998
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A randomized trial of three maintenance regimens given after three months of induction therapy with zidovudine, lamivudine, and indinavir in previously untreated HIV-1-infected patients
Article Abstract:
HIV patients may need to take triple-drug therapy for many years to suppress viral reproduction. Triple-drug therapy usually includes a protease inhibitor plus two other AIDS drugs. Researchers randomly assigned 279 HIV patients whose blood virus levels became undetectable after two months of triple-drug therapy to continue triple-drug therapy or take two of the drugs only. Viral levels rose again in about one-third of the patients taking two drugs, but this happened in only 10% of those who continued taking all three drugs.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1998
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