ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor
Article Abstract:
The addition of 5-hydroxy-1,7-bis(3,4-dimethoxyphenyl)-1,4,6-heptatrien-3-one (ASC-J9) is shown to disrupt the interaction between androgen receptor (AR) and its coregulator and also increase the cell survival by decreasing AR-polyQ nuclear aggregation and increasing AR-polyQ degradation in cultured cells. The results have provided a better therapeutic and preventive approach for treating spinal and bulbar muscular atrophy, by disrupting the interaction between AR and AR coregulators.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
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17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration
Article Abstract:
The therapeutic effects of 17-allylamino-17-demethoxygeldanamycin (17-AAG), a potent Hsp90 inhibitor, and its ability to degrade polyglutamine-expanded mutant androgen receptor (AR) are examined. The mutant AR showed a higher affinity for Hsp90-p23 and preferentially formed an Hsp90 chaperone complex as compared to wild-type AR.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Leuprorelin rescues polyglutamine-dependent phenotypes in a transgenic mouse model of spinal and bulbar muscular atrophy
Article Abstract:
The effect of androgen-blockade drugs on the transgenic mouse model was examined. Leuprorelin that seems to be a promising candidate for the treatment of spinal and bulbar muscular atrophy (SBMA) is discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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