Hypothalamic sensing of circulating fatty acids is required for glucose homeostasis
Article Abstract:
Physiological increments in plasma fatty acids could be sensed within the hypothalamus and could be used to balance their direct stimulatory action on hepatic gluconeogenesis. Experiments indicate that a physiological elevation in circulating lipids could be sensed within the hypothalamus and that a defect in hypothalamic lipid sensing disrupts glucose homeostasis.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
Comment about this article or add new information about this topic:
Inhibition of hypothalamic carnitine palmitoyltransferase-1 decreases food intake and glucose production
Article Abstract:
The enzyme carnitine palmitoytransferase-1 (CPT 1) regulates long-chain fatty acid entry into mitochondria, where the LCFAs undergo beta-oxidation. To substantially diminish food intake and endogenous glucose production, the genetic or biochemical inhibition of hypothalamic CPT1 activity was sufficient.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
User Contributions:
Comment about this article or add new information about this topic:
Brain glucose metabolism controls the hepatic secretion of triglyceride-rich lipoproteins
Article Abstract:
A selective increase in brain glucose has lowered circulating triglycerides (TG) through the inhibition of TG-very low-density lipoprotein (VLDL) secretion by the liver. The results have indicated that a defect in brain glucose sensing might play a key role in the etiology of the metabolic syndrome.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2007
User Contributions:
Comment about this article or add new information about this topic:
- Abstracts: Inhaled nitric oxide in premature infants with the respiratory distress syndrome. Nitric oxide for preemies -- not so fast
- Abstracts: Diurnal rhythms of labor and delivery in women: modulation by parity and seasons
- Abstracts: Hugo Barrera-Saldana. Controlling immune response may cut bird flu death rate. The heart of the matter
- Abstracts: Angiogenesis in life, disease and medicine. Regulation of angiogenesis by tissue factor cytoplasmic domain signaling
- Abstracts: Recombinant modified vaccinia virus Ankara expressing antigen 85A boosts BCG-primed and naturally acquired antimycobacterial immunity in humans