All-trans-retinoic acid in acute promyelocytic leukemia
Article Abstract:
All-trans-retinoic acid appears to be significantly better than chemotherapy in the treatment of acute promyelocytic leukemia. Researchers randomly assigned 346 patients with this type of leukemia to receive all-trans-retinoic acid or chemotherapy with daunorubicin and cytarabine. Remission rates were 69% in the chemotherapy group and 72% in the all-trans-retinoic group. Those with the lowest 1-, 2-, and 3-year survival rates were those who received chemotherapy alone but no maintenance treatment with all-trans-retinoic acid following remission. Patients who received all-trans-retinoic acid had significantly higher survival rates.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1997
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Positron-emission tomography and assessment of cancer therapy
Article Abstract:
Positron-emission tomography (PET) is a noninvasive imaging technique that exploits the unique decay of positron-emitting isotopes of oxygen, carbon, nitrogen and fluorine for development of diagnostically useful biological compounds available for PET to provide a functional or metabolic assessment of normal tissues or disease conditions. PET is evaluated for its ability to predict response or lack of response at very early stage in the course of treatment.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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Fludarabine compared with chlorambucil as primary therapy for chronic lymphocytic leukemia
Article Abstract:
Fludarabine may be effective in treating chronic lymphocytic leukemia that does not respond to chlorambucil. In a study of 509 patients, fludarabine resulted in higher response rates and longer remissions but did not improve overall survival rates.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2000
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