Aminotransferase elevations in healthy adults receiving 4 grams of acetaminophen daily: A randomized controlled trial

Article Abstract:

A study was conducted to characterize the incidence and magnitude of serum alanine aminotransferase (ALT) elevations in healthy participants receiving 4g of acetaminophen daily, either alone or in combination with selected opioids, as compared with participants treated with placebo. It was found that initiation of recurrent dally intake of 4g acetaminophen in healthy adults is associated with ALT elevations and concomitant treatment with opioids does not increase this effect.

Specialty outpatient clinics, not elsewhere classified, Outpatient Mental Health and Substance Abuse Centers, Alcohol & Drug Abuse Programs, Acetaminophen-Based Analgesics, Health aspects, Substance abuse, Acetaminophen, Substance abuse treatment, Alanine aminotransferase

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Radio frequency ablation vs. antiarrhythmic drugs as first-line treatment of symptomatic atrial fibrillation: A randomized trial

Article Abstract:

An attempt is made to determine whether pulmonary vein isolation (PVI) is feasible as first-line therapy for treating patients with symptomatic atrial fibrillation (AF). It is found that pulmonary vein isolation appears to be a feasible first-line approach for treating patients with symptomatic atrial fibrillation and larger studies are needed to confirm its safety and efficacy.

Antiarthritic Analgesic Preps, Usage, Diagnosis, Atrial fibrillation, Antiarthritic agents, Pulmonary veins, Pulmonary vein

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Effect of tilarginine acetate in patients with acute myocardial infarction and cardiogenic shock: The TRIUMPH randomized controlled trial

Article Abstract:

The effects of an isoform-nonselective nitric oxide synthase (NOS) inhibitor in patients with myocardial infarction (MI) and refractory cardiogenic shock despite establishment of an open infarct artery were studied. The results showed that tilarginine did not reduce mortality rates in patients with refractory cardiogenic shock complicating MI, despite an open infarct artery.

Cardiovascular Preparations, Heart attack, Dosage and administration, Cardiovascular agents, Cardiogenic shock

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