An association between the risk of cancer and mutations in the HRAS1 minisatellite locus
Article Abstract:
There appears to be a significant correlation between rare HRAS1 alleles and certain types of cancer. Alleles are alternative forms of a gene that occupy similar locations on paired chromosomes. Molecular analysis of 736 HRAS1 alleles from white cancer patients and 652 from white patients without cancer was performed. A meta-analysis of 23 related studies involving only white patients was also done. The rare HRAS1 alleles occurred 1.8 times more frequently in patients with cancer. These alleles appeared to be associated with acute leukemia, colorectal cancer, breast cancer and cancer of the urinary bladder. The meta-analysis of the 23 studies also revealed a significant increase in the risk of cancer in people carrying the rare alleles.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1993
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Managed care arrives in Latin America
Article Abstract:
The entry of managed care into Latin America could be beneficial if the managed care companies are not strictly motivated by profit. A 1999 study found that some managed care companies are moving into Latin America to escape regulation by the US government. They see Latin America as a chance for making unlimited profits. Latin America has a surplus of doctors, many of whom may agree to work for low wages. One managed care company operating a plan in Buenos Aires only pays doctors in capitated plans $8 to $18 per patient per month.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 1999
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The importance of race and ethnic background in biomedical research and clinical practice
Article Abstract:
The importance of racial and ethnic categories in epidemiological and clinical research is discussed. Topics include race and ethnic background as constructs with biologic ramifications, sociocultural correlates of race and ethnic background, genetic differentiation among races, genetic differences in disease outcomes, racially mixed populations, and the risks of ignoring race in biomedical research and clinical practice.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2003
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