Analysis of a large collection of natural HIV-1 integrase sequences, including those from long-term nonprogressors
Article Abstract:
Variations in the HIV enzyme called integrase are not responsible for the lack of progression of HIV infection in some people. Integrase is one of the three viral enzymes that allow HIV to reproduce. It inserts the DNA of the virus into the DNA of the cell it infects. Researchers analyzed the sequence of the enzyme in blood or white blood cells from 10 hemophilia patients, five of whom show no signs of HIV infection 12 or more years after becoming infected. There were no significant differences in enzyme sequence between them and the five patients who developed AIDS and died.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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Research potentials and pitfalls in the use of an HIV clinical database: Chelsea and Westminster Hospital
Article Abstract:
A large clinical database on the development, progression, and treatment of HIV infection in 6,653 patients in London, England, provides important information to researchers and physicians. Gay and bisexual men make up 83% of enrolled patients, and a third of all patients in the study have progressed to clinical AIDS. The database collects information for local disease surveillance and reporting, provides up-to-date clinical summaries of patients, and is used to identify patients appropriate for participation in clinical trials.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
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Does pregnancy influence the course of HIV infection? Evidence from two large Swiss cohort studies
Article Abstract:
Pregnancy does not appear to influence the progression of HIV infection. Researchers in Switzerland compared 32 pregnant, HIV-infected women and 416 HIV-infected women who were not pregnant. During approximately four years, the rate of recurrent bacterial pneumonia was substantially higher in pregnant women. The rates of other AIDS-defining illnesses were similar in both groups. Pregnancy does not seem to accelerate the course of HIV infection or the development of AIDS.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1998
User Contributions:
Comment about this article or add new information about this topic:
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