Angiogenic synergism, vascular stability and improvement of hind-limb ischemia by a combination of PDGF-BB and FGF-2
Article Abstract:
Research demonstrates the synergistic induction of vascular networks by a combination of two angiogenic factors, platelet-derived growth factor-BB and fibroblast growth factor-2 therapy. Furthermore, the angiogenic factors stimulate collateral arteriogenesis in the ischemic hind limbs following ligation of the femoral artery in both rat and rabbit.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Long-term cure of the photosensitivity of murine erhthropoietic protoporphyria by preselective gene therapy
Article Abstract:
The photosensitivity of erythropoietic protoporphyria in mice might be treated using preselective gene therapy. So far no real cure of an animal model of a human disease has been achieved using gene transfer into hematopoietic stem cells in the absence of spontaneous in vivo selection for transduced cells.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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Cartilage to bone - angiogenesis leads the way
Article Abstract:
Vascular endothelial growth factor (VEGF) has a vital role in longitudinal bone growth by stimulating angiogenesis into the epiphyseal growth plate. Soluble VEGF receptors target only newly forming blood vessels apparently not affecting blood vessels already in existence.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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