Antenatal steroids, delivery mode, and intraventricular hemorrhage in preterm infants

Article Abstract:

Cesarean delivery and treatment with steroids before birth appear to reduce the incidence of brain hemorrhage in very-low-birth-weight infants during the first hours after birth. The protective effect appeared to be additive. However, infants born vaginally and whose mothers were not given steroids were younger and weighed less, which could affect differences in outcome. A group of 505 infants weighing 600 to 1250 g at birth and with an average gestational age 27 to 28 weeks had an ultrasound scan of the brain 5 to 11 hours after birth. Seventy-three had had an intraventricular hemorrhage. Among infants having a hemorrhage, 19% had received steroid treatment before birth and 32% had not, and 71% were delivered by cesarean versus 45% born vaginally. Among the 152 infants treated with steroids, 4% of cesarean deliveries had a hemorrhage versus 17% of vaginal births. Among the 353 not treated with steroids, 10% of cesarean deliveries had a hemorrhage versus 22% of vaginal births.

Risk factors, Infants (Premature), Premature infants, Hemorrhage, Cesarean section, Steroids (Drugs)

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Antecedents of cerebral palsy in a multicenter trial of indomethacin for intraventricular hemorrhage

Article Abstract:

Ultrasound (US) examination of the head may be useful in predicting cerebral palsy (CP) in very-low-birthweight infants. A number of factors before, during and after birth may influence the development of this form of mental retardation. Researchers examined 381 infants with birth weights of 600-1250 grams. CP was found in 9.5% of the infants. Treatment with indomethacin did not appear to affect the CP rate. US identified bleeding or enlargement of brain cavities as predictive of CP in the first few days of life. Other disorders predicted CP in the first three years of life.

Evaluation, Diagnosis, Medical examination, Cerebral palsy, Birth weight, Low, Low birth weight, Infants (Newborn), Neonatal screening, Indomethacin, Ultrasonic encephalography

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Regional Brain Volume Abnormalities and Long-term Cognitive Outcome in Preterm Infants

Article Abstract:

Premature birth may stunt brain growth in some parts of the brain, according to a study of 25 eight-year-old children born prematurely and 39 children who were born at term. The premature children also had lower IQ scores.

Causes of, Physiological aspects, Growth, Brain, Premature birth, Cognition disorders, Cognitive disorders

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