Anti-alpha-1(IV) collagen antibodies associated with lung adenocarcinoma presenting as the Goodpasture syndrome
Article Abstract:
A type of lung cancer may mimic a disease known as the Goodpasture syndrome. Goodpasture syndrome is a kidney disease caused by inflammation and antibodies against the basement membrane in kidney tissue. A 72-year-old man with symptoms of coughing up blood and an abnormal chest x-ray was found to have a high level of antibodies against kidney basement membrane. He was treated for Goodpasture syndrome, and his condition improved until the 26th hospital day. Fluid collected in his right lung, which was later found to be cancerous. He died shortly after the diagnosis was made. The cause of the man's symptom of coughing up blood may have been a lung tumor that did not appear on bronchoscopy. To distinguish Goodpasture syndrome from lung cancer, specific and sensitive laboratory tests for antibodies should be used.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1996
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Language guiding therapy: the case of dehydration versus volume depletion
Article Abstract:
Careful diagnosis and discrimination between the two disorders, dehydration and volume depletion, can be facilitated by precise use of the correct terms. Dehydration primarily occurs from loss of water from the skin, gut, or kidneys, and results in high sodium levels in the blood. This then leads to loss of water from inside the cells of the body. Volume depletion is usually due to blood loss or a reduction in total body sodium content. Water loss is mainly from the non-cellular spaces with depletion of total circulatory volume. Appropriate treatment depends on the correct diagnosis.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 1997
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Long-term outcome of patients with kidney damage due to Goodpasture disease who receive very intensive treatment
Article Abstract:
Some patients with severe Goodpasture's syndrome can still benefit from intensive therapy using plasma exchange, corticosteroids, and immunosuppressive drugs. Goodpasture's syndrome is an autoimmune disease that causes kidney failure.
Publication Name: Annals of Internal Medicine
Subject: Health
ISSN: 0003-4819
Year: 2001
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