Maternal age influences risk for HLA-B27 associated ankylosing enthesopathy in transgenic mice
Article Abstract:
The risk for offspring developing ankylosing enthesopathy (AE) may decrease as the mother's age increases. AE is a disorder in mice involving the fusing of muscles and tendons to bone and is a model for studying human spinal joint disease. Researchers followed three groups of breeding mice at different ages to determine the risk in the offspring for developing AE. All of the mice contained genes that have been associated with joint disease in mice and humans. Mice younger than 8 months produced approximately twice as many offspring with AE as those mice 8 months or older. The relevance of this study to human spinal joint disease is unclear.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1995
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Grouped caging predisposes male mice to ankylosing enthesopathy
Article Abstract:
Caging male mice together may predispose them to development of andylosing enthesopathy (ANKENT). ANKENT is a disease with marked similarities to human seronegative spondyloarthropathies, including that it occurs more frequently in older males and the same genetic abnormality causes a predisposition to the disease. No males caged alone developed the disease, and few males caged with females developed the disease. However, males caged with males were more likely to develop the disease. This suggests that male-to-male proximity causes some stress of the immune system or perhaps spreads an infection through biting or other mechanisms.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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Enthesopathy and tendinopathy in gout: computed tomographic assessment
Article Abstract:
Computed tomography (CT) appears to be a valuable imaging tool for detecting the characteristic salt deposits called monosodium urate seen in tendon and muscle damage of patients with gout. CT scans and standard X rays were taken of three patients with gout and complications in either the knee or Achilles tendon. Opaque areas were visible on all three CT scans of the tendons. These areas were not apparent on the X rays.
Publication Name: Annals of the Rheumatic Diseases
Subject: Health
ISSN: 0003-4967
Year: 1996
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