Anticardiolipin antibodies and the risk for ischemic stroke and venous thrombosis

Article Abstract:

Healthy adult men with increased blood levels of anticardiolipin antibodies may have a higher risk of a blood clot forming in the lung (pulmonary embolus) or the large veins of the leg (deep vein thrombosis) than other individuals. Anticardiolipin antibodies are antibodies against certain types of phospholipids, or fats. A study measured the blood levels of immunoglobulin G anticardiolipin antibodies in 20,071 men and compared these measurements to the incidence of stroke, deep venous thrombosis and pulmonary embolus among these individuals over an average of five years. Individuals who developed deep venous thrombosis or a pulmonary embolus had significantly higher blood levels of cardiolipin antibodies than those who did not. Men who suffered a stroke did not have significantly higher blood levels of anticardiolipin antibodies than those who did not.

Thrombophlebitis, Anticardiolipin antibodies

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Inflammation, aspirin, and the risk of cardiovascular disease in apparently healthy men

Article Abstract:

Measuring blood levels of C-reactive protein may predict which men will subsequently have a heart attack or stroke. C-reactive protein is a marker for inflammation, which is believed to play a role in coronary artery disease. Researchers took blood samples from 22,071 physicians participating in the Physicians' Health Study. Over time, 543 men had a heart attack, stroke or episode of abnormal blood clotting. These men had higher blood levels of C-reactive protein than a group of 543 men who were still healthy. Men with the highest levels had 3 times the risk of heart attack or stroke than men with the lowest levels.

Measurement, Heart attack, Inflammation, Inflammation mediators, C-reactive protein

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Age-specific incidence rates of venous thromboembolism among heterozygous carriers of factor V Leiden mutation

Article Abstract:

Older people with factor V Leiden mutations are just as likely to develop a thromboembolic event as young people who have the mutation. Thromboembolism occurs when a blood clot forms and travels to another part of the body. Researchers tested for the factor V Leiden mutation in 156 men in the Physicians' Health Study who developed thromboembolism and 2,406 men in the study who did not. Those older than 50 who had the mutation were more likely to develop thromboembolism than those who did not. The mutation interferes with blood clotting.

Gene mutations, Gene mutation, Genetic aspects, Thromboembolism, Blood coagulation factors

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