Antiendometrial antibodies in endometriosis measured by an enzyme-linked immunosorbent assay before and after treatment with danazol and nafarelin

Article Abstract:

Endometriosis is a condition causing cells which normally line the inside of the uterus to grow and function outside the uterus, typically in regions of the abdominal wall and pelvis. Some women with endometriosis produce antibodies, known as autoantibodies, against endometrial tissue. The significance of these autoantibodies in women with endometriosis is unclear, but the antibodies may be produced in response to the growth of endometrium outside the uterus, which could be perceived by the immune system as a foreign substance. It is thought that these antibodies may cause infertility in some women with endometriosis by preventing the fertilized embryo from implanting in the uterus. To determine whether treatment with medications alters the level of antiendometrial antibodies, 35 women with confirmed endometriosis were studied. Two treatment regimens were used: danazol, which affects the pituitary gland; and nafarelin, a drug that mimics the action of gonadotropin releasing hormone (GnRH). Both drugs act by shrinking endometrial tissue. Eleven women received danazol and 24 women took nafarelin, for six months. The antiendometrial antibodies were measured before and after treatment. Antibody levels were significantly lowered in the nafarelin-treated group only; antibodies were also lowered by danazol, but not to a significant extent. It is concluded based on this and previous studies that nafarelin and danazol most likely both reduce the level of antiendometrial antibodies produced by women with endometriosis. Such an effect had not been previously seen with use of nafarelin, but only with danazol. (Consumer Summary produced by Reliance Medical Information, Inc.)

Usage, Measurement, Autoantibodies, Physiological aspects, Drug therapy, Enzyme-linked immunosorbent assay, Endometriosis, Danazol, Nafarelin

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The impact of treatment for gynecological cancer on health-related quality of life (HRQoL): A systematic review

Article Abstract:

Several studies have reported on the impact of gynecologic cancers on health related quality of life (HRQoL) but none have reviewed the evidence in specific relation to the effect of treatment on HRQoL. It is found that only 47 studies used a validated questionnaire to measure HRQoL, thus suggesting future reporting of HRQoL in gynecologic oncology studies.

United States, Science & research, Public affairs, Health aspects, Social aspects, Care and treatment, Women, Cervical cancer, Quality of life, Women's health

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Chronic pelvic pain in the community symptoms, investigations, and diagnoses

Article Abstract:

Many women with chronic pelvic pain also have menstrual disorders, pain during intercourse, or irritable bowel syndrome. In a study of 483 women with chronic pelvic pain, half had one or more of these conditions.

Pelvic pain

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