Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies

Article Abstract:

The promise and challenges for short cationic antimicrobial peptides comprising potent and broad-spectrum molecules that have many desirable properties are described. It is concluded that the role of cationic host-defense peptides in modulating the innate immune response and boosting infection-resolving immunity while dampening potentially harmful pro-inflammatory (septic) responses make them an entirely new therapeutic approach against bacterial infections.

United States, Bacterial infections

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Using the amide proton signals of intracellular proteins and peptides to detect pH effects in MRI

Article Abstract:

The possibility to produce pH-sensitive MRI contrast by exploiting the exchange between the hydrogen atoms of water and the amide hydrogen atoms of endogenous mobile cellular proteins and peptides are mentioned. Although amide proton concentrations are in the millimolar range, a detection sensitivity of several percent on the water signal was achieved.

Drugs, Cellular Protein, In-Vitro Diagnostic Substance Manufacturing, Cellular proteins, Hydrogen-ion concentration

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Salusins: newly identified bioactive peptides with hemodynamic and mitogenic activities

Article Abstract:

A lengthy identification process has been required for the discovery of endogenous bioactive peptides . Unidentified bioactive peptides resulted in identification of two related peptides of 28 and 20 amino acids, w3hich are designated salusin-alpha and salusin-beta.

Identification and classification, Amino acids

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