Protein microarrays for multiplex analysis of signal transduction pathways
Article Abstract:
A multiplexed reverse phase protein (RPP) microarray platform for simultaneous monitoring of site specific phosphorylation of numerous signaling proteins using nanogram amounts of lysates derived from stimulated living cells is discussed. RPP microarrays, prepared using simple procedures and standard microarray equipment, represent a powerful new tool for the study of signal transduction in both health and disease.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2004
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CD4+CD25+ regulatory T cells preserve graft-versus-tumor captivity while inhibiting graft-versus-host disease after bone marrow plantation
Article Abstract:
Graft-versus-host disease (GVHD), are the main mediators of the beneficial graft-versus-tumor (GVT) activity of allogenic bone marrow transplantation. It is shown that donor-derived CD4+CD25+ T cells inhibit lethal GVHD after allogenic bone marrow transplantation across major histocompatibility complex (MHC) class one and two barriers in mice.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Memory stem cells sustain disease
Article Abstract:
A study to identify a subset of postmitotic CD8(super +) T cells that persist throughout the course of graft-versus-host disease (GVHD) and are responsible for host injury after transplantation is presented. The study showed that CD8(super +) memory stem cells specific against recipient antigens trigger GVHD.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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