Antimullerian hormone as a serum marker of granulosa cell tumors of the ovary: comparative study with serum alpha-inhibin and estradiol
Article Abstract:
The presence and recurrence of granulosa cell tumors of the ovaries may be marked by higher blood levels of antimullerian hormone (AMH). Researchers measured blood levels of AMH in 16 patients with adult-type granulosa cell tumors; in patients with ovarian adenocarcinoma, benign ovarian cysts, or cancers outside the ovary; and in healthy women. AMH levels were low in healthy women, were normal in 93% of women with ovarian cancers, cysts, or extraovarian cancers, and were elevated in patients with granulosa cell tumors. AMH may predict disease recurrence. Blood levels of AMH became elevated in two women who were thought to be in remission from granulosa cell tumors, but who developed the tumors again 11 months and two years later. AMH may be a better tumor indicator than estradiol.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1996
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17-beta-estradiol, progesterone, and testosterone inversely modulate low-density lipoprotein oxidation and cytotoxicity in cultured placental trophoblast and macrophages
Article Abstract:
A form of estrogen called 17-beta-estradiol appears to limit cell death and plaque formation as measured by low-density lipoprotein (LDL) oxidation factors within placental tissue. Progesterone and testosterone, however, appear to enhance these effects. Tissue samples from six full-term placentas were used to analyze the effects on LDL oxidation and cell death when exposed to 17-beta-estradiol or progesterone and testosterone. LDL oxidation decreased when exposed to 17-beta-estradiol but increased when exposed to progesterone and testosterone. Cell death rates were lower in the presence of 17-beta-estradiol compared to progesterone and testosterone.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1997
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Macrosomia revisited: ponderal index and leptin delineate subtypes of fetal overgrowth
Article Abstract:
An asymmetric ponderal index and elevated leptin levels are a more accurate indicator of fetal macrosomia. Ponderal index is a better way of detecting large-for-gestational-age infants.
Publication Name: American Journal of Obstetrics and Gynecology
Subject: Health
ISSN: 0002-9378
Year: 1999
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