Elevated serum levels of endometrial secretory protein PP14 in patients with advanced endometriosis

Article Abstract:

The secretory endometrial cells that line the inside of the uterus release a placental protein known as PP14. The amount of PP14 secreted changes during phases of the menstrual cycle. It has been found that the relative amount of PP14 secreted indicates the secretory activity of the endometrium. The amount of PP14 in the blood was used to measure protein secretion in 77 patients with endometriosis, the abnormal implantation of endometrial tissue, normally found inside the uterus, elsewhere in the body. The levels of PP14 were highest during the first four days and the lowest on days 5-20 of the menstrual cycle. Patients with severe endometriosis had higher levels of PP14 on the low days than patients with mild endometriosis, who had higher levels than the normal controls. There was overlap between the three groups. Treatment for endometriosis, which included surgical removal of diseased tissue alone or in combination with drug therapy using danazol or medroxyprogesterone, was found to lower PP14 concentrations. It is concluded that PP14 secretion is elevated in patients with endometriosis and treatment of the condition effectively lowers PP14.

Measurement, Placenta, Pregnancy proteins

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Pelvic endometriosis mimicking advanced ovarian cancer: presentation with pleural effusion, ascites, and elevated serum CA 125 level

Article Abstract:

Endometriosis may resemble advanced ovarian cancer in some women. Endometriosis is a buildup of blood and tissue in the uterus and abdomen that can cause pain. A 65-year-old postmenopausal woman and a 47-year-old premenopausal woman experienced shortness of breath, excess fluid in the lungs and abdomen, and elevated blood levels of a tumor antigen called CA 125. Because of these symptoms, they were presumed to have advanced ovarian cancer. Both women underwent total abdominal hysterectomies. Laboratory analysis revealed endometriosis but no malignancy. Endometriosis may cause abdominal adhesions and the buildup of fluid and blood in the abdomen which may also invade the lungs. A correct diagnosis may be necessary to preserve fertility in young women with endometriosis that resembles ovarian cancer.

Ovarian cancer

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Uterine innervation after hysterectomy for chronic pelvic pain with, and without, endometriosis

Article Abstract:

Patterns of uterine innervation were studied after hysterectomy to determine chronic pelvic pain with and without endometriosis. Observation of such patients showed that there were no quantitative differences in groups with chronic pelvic pain and endometriosis.

United States, Care and treatment, Patient outcomes, Hysterectomy, Pelvic pain

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