Antiviral activity of nucleoside analogues during short-course monotherapy or dual therapy: Its role in preventing HIV infection in infants

Article Abstract:

The preliminary efficacy of four different short-course nucleoside analogue regimens, stavudine (d4T), didanosine (ddI), d4T+ddI, and zidovudine are reported for the prevention of mother-to-child transmission of HIV-1 in a response-limited setting. The use of monotherapy in the study afforded the opportunity to demonstrate the relative intrinsic activity of several nucleoside analogues, while the results suggested that of the three nucleoside analogues evaluated in monotherapy, ddI was the most potent.

Biological Product (except Diagnostic) Manufacturing, Nucleic Acid Derivatives, Health aspects, Usage, Prevention, HIV infection in children, Pediatric HIV infections, Antiviral agents, Nucleosides, Clinical report

---

Mother-to-child transmission of HIV-1: strong association with certain maternal HLA-B alleles independent of viral load implicates innate immune mechanisms

Article Abstract:

A child shares major histocompatibility complex (MHC) genes with its mother due to which the transmission of HIV-1 from mother to child is different from other types of HIV-1 transmission. The relevance of these immune mechanisms to HIV-1 transmission is assessed by determining the HLA-B alleles of mother and child.

Genetic aspects, Communicable diseases, AIDS (Disease), AIDS research

---

Tolerance and safety of different concentrations of chlorhexidine for peripartum vaginal and infant washes: HIVNET 025

Article Abstract:

Different concentrations for perinatal maternal and infant washes are examined to identify the maximum tolerable concentration of chlorhexidine (CHX) for an intervention. The sustainable need to prevent HIV type 1 transmission from mother-to-child is evaluated.

Care and treatment, HIV (Viruses), HIV, HIV patients, Chlorhexidine

Similar abstracts:

• Abstracts: National use of postmenopausal hormone therapy: annual trends and response to recent evidence. Impact of clinical trial results on national trends in alpha-blocker prescribing, 1996-2002
• Abstracts: Associations of sexual risk taking among Kenyan female sex workers after enrollment in an HIV-1 prevention trial
• Abstracts: Efficacy of B-cell-targeted therapy with rituximab in patients with rheumatoid arthritis
• Abstracts: Influence of peak viral load on the extent of CD4(super +) T-cell depletion in Simian HIV infection. Virus dynamics and immune responses during treatment in patients coinfected with hepatitis C and HIV
• Abstracts: Serious adverse coetaneous and hepatic toxicities associated with Nevirapine use by non-HIV-infected individuals

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.