Antiviral drug resistance
Article Abstract:
The first report of cytomegalovirus (CMV) resistance to the drug ganciclovir occurred in 1989. All three patients had been taking the drug for a relatively long period of time. CMV was first reported to be resistant to foscarnet in 1991, and in 1995, several CMV strains were found that were resistant to both drugs. The most common assays used to detect drug resistance are the plaque reduction assay and a DNA hybridization assay. However, they can give different results so standards are needed. Mutations in the viral UL97 and UL54 genes are the most common cause of resistance.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Current knowledge base, trends, and current thinking
Article Abstract:
In 1995, four cytomegalovirus (CMV) isolates from four different patients were found to be resistant to ganciclovir and foscarnet, the two approved drugs for CMV infection. All of the isolates had mutations in the viral genes UL97 and pol. Research on these strains indicates that they all developed from the same strain and the mutations were added as the strain evolved. However, drug resistance is still uncommon, occurring in fewer than 1% of patients taking drugs to prevent CMV and in 8% of those who take the drugs to treat CMV infection.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
Background
Article Abstract:
Many healthy adults have been exposed to cytomegalovirus (CMV) by the time they reach middle age, but most do not develop disease. This is not true in people who have damaged immune systems, such as those with HIV infection or those receiving an organ transplant. These patients can develop serious CMV disease. The only drugs approved by the FDA to treat CMV infection are ganciclovir and foscarnet. Both are very effective in treating CMV infection and ganciclovir is also effective in preventing infection.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
User Contributions:
Comment about this article or add new information about this topic:
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