Apolipoprotein E status as a predictor of the development of Alzheimer's disease in memory-impaired individuals

Article Abstract:

Elderly people with mild cognitive impairment (MCI) who have the apolipoprotein E 4 (apo E 4) allele may be more likely to progress to Alzheimer's disease than those who have other forms of the apo E gene. Researchers administered cognitive tests to 66 elderly patients with MCI at 18-month intervals to observe the progression of cognitive impairment. Investigators took blood samples from the patients to study the relationship between apo E status and disease progression. At the 18-month follow-up, 24% of patients had progressed to dementia. Of those who had subsequent follow-ups, 44% progressed to dementia in an average of 36 months and 55% progressed to dementia in an average of 54 months. Those who carried the apo E 4 allele were more than four times more likely to develop dementia than patients who had other forms of the apo E gene.

Development and progression, Memory disorders in old age, Geriatric memory disorders

---

Prevalence of parkinsonian signs and associated mortality in a community population of older people

Article Abstract:

Parkinsonism occurs commonly among the aged and people who have it may have twice the risk of dying than people who do not. Parkinsonism is characterized by symptoms such as tremor, rigid muscles, abnormal gait, and slow movement. Researchers performed neurologic exams on 467 people in a community who were aged 65 and older. Parkinsonism occurred in 159 of these people and its prevalence increased with age. The prevalence ranged from 15% among people aged 65 to 74, to 52% among people aged over 85. During an average follow-up of 9.2 years, the mortality rate was 78% among people with parkinsonism and 49% among people without it. When a statistical adjustment was made for age and sex, parkinsonism appeared to double the risk of death.

Aged, Elderly, Patient outcomes, Mortality, Parkinsonism, Symptomatic, Secondary Parkinson disease

---

Apolipoprotein E epsilon4 and incidence of Alzheimer disease in a community population of older persons

Article Abstract:

The apolipoprotein E (APOE) epsilon4 gene appears to be linked to a very small percentage of cases of Alzheimer's disease. In a study of 578 residents of East Boston, 88 were diagnosed with probable Alzheimer's disease. However, of the 85 people in the entire group who had one copy of the APOE epsilon4 gene, only 17 were diagnosed with Alzheimer's disease. Of the 6 people with two copies of the gene, only 2 were diagnosed with Alzheimer's disease. Most of the people with Alzheimer's disease in this population did not have the APOE epsilon4 gene. This indicates that other factors may be responsible for the disease.

Similar abstracts:

• Abstracts: Factors associated with the development of vasculitis in rheumatoid arthritis: results of a case-control study
• Abstracts: Azithromycin compared with amoxicillin in the treatment of erythema migrans: a double-blind, randomized, controlled trial
• Abstracts: Planning for success. Good practice management often missing in mergers
• Abstracts: The clinical utility of serum uric acid measurements in hypertensive diseases of pregnancy. Is there a benefit to episiotomy at spontaneous vaginal delivery? A natural experiment
• Abstracts: Serum beta2-microglobulin and prediction of progression to AIDS in HIV-infected injection drug users. Quantitative alterations of the functionally distinct subsets of CD4 and CD8 T lymphocytes in asymptomatic HIV infection: changes in the expression of CD45RO, CD45RA, CD11b, CD38, HLA-DR, and CD25 antigens

This website is not affiliated with document authors or copyright owners. This page is provided for informational purposes only. Unintentional errors are possible.