Serum beta2-microglobulin and prediction of progression to AIDS in HIV-infected injection drug users
Article Abstract:
The concentration of beta2-microglobulin in the blood may be a useful indicator in identifying HIV-infected patients with an increased risk of developing AIDS. Researchers analyzed the blood of 130 HIV-positive intravenous drug users and found that the strongest predictor of progression to AIDS was a low CD4+ cell count at the start of the study. Increases in blood levels of beta2-microglobulin, which indicates stimulation of the immune system, predicted how soon patients would develop AIDS. The predictive value of beta2-microglobulin was significant when CD4+ cell counts exceeded 500. The study followed participants for 67 months. Study findings of this group of injection drug users agreed with previous findings among HIV-infected homosexuals.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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CD8+, CD38+ lymphocyte percent: a useful immunological marker for monitoring HIV-1-infected patients
Article Abstract:
An increase in the CD38+ subset of CD8+ T lymphocytes may predict an increase in the risk of AIDS in HIV-infected patients. Researchers regularly measured blood levels of CD8+ CD38+ lymphocytes, beta2-microglobulin, and CD4 lymphocytes in 224 patients. Within 32 months, 34 patients had progressed to AIDS. All of the markers were associated with AIDS progression. A 10% rise in the expression of the CD38+ subset was associated with an 37% rise in the risk of developing AIDS after adjusting for CD4 and beta2-microglobulin counts.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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Quantitative alterations of the functionally distinct subsets of CD4 and CD8 T lymphocytes in asymptomatic HIV infection: changes in the expression of CD45RO, CD45RA, CD11b, CD38, HLA-DR, and CD25 antigens
Article Abstract:
During HIV infection, the destruction of naive T cells apparently occurs at a faster rate than the destruction of memory T cells. This was demonstrated in a study that analyzed the changes in blood levels of specific subsets of CD4 and CD8 T lymphocytes in 116 people with asymptomatic HIV infection. The CD45RO+ subsets of both CD4 and CD8 lymphocytes increased while the CD45RO-CD45RA T cell levels decreased. Levels of CD11b- subsets of CD8 lymphocytes declined while levels of CD11b+ subsets increased.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1997
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