Approaches to microRNA discovery

Article Abstract:

MicroRNAs (miRNAs) are RNA molecules of approximately 22 nucleotides derived from the genome-encoded stem-loop precursors that recognize target mRNAs by base-pairing and thereby regulate their expression. Advances in the methodology used to discover miRNAs are reviewed and the standards used for miRNA classification in connection with the progress in the understanding of miRNA biology are discussed, highlighting work done in animal studies.

Gene expression, Messenger RNA

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Antiproliferative activity of ecteinascidin 743 is dependent upon transcription-coupled nucleotide-excision repair

Article Abstract:

Et743 interacts with the transcription-coupled nucleotide excision repair (NER) machinery to induce lethal DNA strand breaks. Studies of cells deficient in XPC or in the genes implicated in Cockayne syndrome (CSA and CSB) indicated that the drug sensitivity is specifically dependent on the transcription-coupled pathway NER.

Care and treatment, Cockayne syndrome

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Nucleotide-sugar transporter SLC35D1 is critical to chondroitin sulfate synthesis in cartilage and skeletal development in mouse and human

Article Abstract:

The significance of the solute carrier-35 D1 (SLC35D1) in promoting chondroitin sulfate synthesis in cartilage and skeletal development in mouse and humans is discussed. The analysis shows that the loss of SLC35D1 mutations can also cause a skeletal dysplasia in humans.

Bones, Genetic aspects, Chondroitin, Mutation (Biology), Mutation, Proteoglycans, Musculoskeletal abnormalities

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