Transient myeloproliferative disorder of the Down type in the normal newborn

Article Abstract:

One of the complications that may occur in children with Down's syndrome is leukemia. Down's syndrome is the result of a chromosome abnormality, which is also referred to as trisomy 21. A particular type of leukemia, which has been termed transient myeloproliferative disorder (TMD), is associated with Down's syndrome. Most Down's syndrome infants with TMD will eventually go into remission without treatment. Two case histories are reported which involved infants who both developed symptoms of leukemia shortly after birth. Test results revealed that, in addition to the leukemia, both infants had the characteristic genetic profile for Down's syndrome, the trisomy 21, but no physical characteristics of Down's syndrome or mental retardation were apparent. In case one, the genetic profile became normal at eight weeks, and in case two the genetic signs of Down's syndrome disappeared after four months. Spontaneous and enduring recovery from TMD also occurred in both cases. Subsequent follow-up examinations of both children continue to be normal. A discussion is presented of the genetic aspects of these two cases, as well as possible explanations for the mechanisms responsible for these two conditions. The close monitoring of such cases, with cytogenetic analysis of blood and marrow cells and tissue evaluations, are essential in order to determine the patient's status. (Consumer Summary produced by Reliance Medical Information, Inc.)

Case studies, Complications and side effects, Prognosis, Genetic aspects, Myeloproliferative disorders, Nonlymphoid leukemia in children

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Clinical and Cardiorespiratory Assessment in Children With Down Syndrome Without Congenital Heart Disease

Article Abstract:

Children with Down syndrome who do not have congenital heart disease can safely under heart and lung function tests before they begin an exercise program. This was the conclusion of researchers who performed these tests on 42 children with Down syndrome but no congenital heart disease. Only two of the children had a normal IQ. The heart and lung function tests revealed low exercise tolerance among many of the children.

Health aspects, Usage, Evaluation, Physical fitness, Pulmonary function tests

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