Brief report: successive occurrence of T-cell and B-cell lymphomas after renal transplantation in a patient with multiple cutaneous squamous-cell carcinomas

Article Abstract:

A case study of a kidney transplant patient who subsequently developed squamous-cell skin cancer, skin T-cell lymphoma and nodal B-cell lymphoma highlights the role of immunosuppression in tumor development. To lower the risk of organ rejection, transplant patients undergo immunosuppression therapy which, however, increases their risk of cancer. Lymphomas are less common, affecting 1% to 2% of transplant patients, and usually they are of B-cell origin. That this patient developed both types of lymphomas and that he developed the T-cell type first is highly unusual. Despite a reduction in immunosuppressive treatment, which normally stops tumor growth, the patient's condition worsened. Ironically, it may have been cessation of immunosuppressive therapy to control the skin cancer that induced the T-cell lymphoma to develop. Then, increasing immunosuppression to control the T-cell lymphoma appears to have brought on an Epstein-Barr virus-related B-cell lymphoma.

Complications and side effects, Physiological aspects, Cancer, Tissue transplantation, Transplantation

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Immunosuppression, skin cancer, and ultraviolet A radiation

Article Abstract:

A demonstration that azathioprine, an immunosuppressant used in organ transplantation, sensitizes DNA to ultraviolet A (UVA) radiation is presented. UVA radiation comprises more than 90 percent of the incident midday solar ultraviolet radiation and is present for more hours of each day and throughout the year than UVB radiation.

Health aspects, Risk factors, Ultraviolet radiation, Immunosuppression

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Skin cancers after organ transplantation

Article Abstract:

Skin cancers are the most common malignant conditions in transplant recipients and accounts for substantial morbidity and mortality in patients. The most common forms of skin cancer in transplant recipients are discussed.

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