CD4+ T-lymphocyte lines developed from HIV-1-seropositive patients recognize different epitopes within the V3 loop
Article Abstract:
CD4+ T cells appear to be capable of reacting to several different amino acid sequences in the variable region 3 (V3) of the gp160 glycoprotein of HIV-1. The gp160 glycoprotein plays an important role in HIV infection. Researchers developed five T cell lines specific for the gp120 and gp160 viral proteins from four HIV-infected people. They measured the response of these T cell lines to truncated forms of the V3 region that contained different sequences, or epitopes. Each T cell line was activated by different epitopes, indicating that there is a cluster of epitopes against which T cells will react. However, the T cell lines did not react against V3 regions from different viral strains.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1996
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Human CD4+ T cells can discriminate the molecular and structural context of T epitopes of HIV gp120 and HIV p66
Article Abstract:
The use of T cells taken from people uninfected with HIV in research for an HIV vaccine may produce inconsistent results that cannot be translated to a person's real exposure to HIV. Researchers took T cells from people who were not infected with HIV, cloned the T cells, and exposed them to certain HIV proteins in a laboratory setting. T cells produced immune responses to certain HIV proteins in some contexts but not in others. These results may be quite different from the reaction of T cells to whole HIV in a human body. HIV peptides should not be included in vaccine experiments until their reactivity with proteins and virus particles is analyzed.
Publication Name: Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology
Subject: Health
ISSN: 1077-9450
Year: 1995
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Natural analogue peptides of an HIV-1 GP120 T-helper epitope antagonize response of GP120-specific human CD4 T-cell clones
Article Abstract:
HIV can create gene mutations that allow it to evade the immune system. These gene mutations arise because the enzyme reverse transcriptase is not completely accurate.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2000
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