CD4+ invariant T-cell-receptor+ natural killer T cells in bronchial asthma
Article Abstract:
The frequency and distribution of CD1d-restricted invariant natural killer T cells in the lungs and peripheral blood of patients with persistent asthma are studied to determine the role of invariant natural killer T cells in human asthma. The results suggest that invariant natural killer T cells in asthma represent a new model in which CD4+ natural killer T cells, along with conventional CD4+ T cells, produce interleukin-4 and interleukin-13, driving the development of inflammation in bronchial asthma.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2006
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Dysfunctional interaction of C/EBP and the glucocorticoid receptor in asthmatic bronchial smooth-muscle cells
Article Abstract:
The data indicate that the proliferation of airway smooth-muscle cells in patients with asthma may result from an absence of C/EBPalpha. Lines of bronchial smooth-muscle cells were established from cells from 20 subjects with asthma. The antiproliferative and the cytokine-inhibitory effects of glucocorticoids are mediated by different signaling pathways are demonstrated.
Publication Name: The New England Journal of Medicine
Subject: Health
ISSN: 0028-4793
Year: 2004
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