Can successful vaccines teach us how to induce efficient protective immune responses?
Article Abstract:
Successful vaccines have often emerged out of empirical observations and have only rarely been the result of a rational use of the continuously increasing immunological knowledge available to scientists. However, a posteriori deciphering of the biological bases for the efficacy of successful vaccines should be an essential component of research efforts directed at the development of new vaccines for the most challenging infectious diseases.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
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Targeting the innate immune response with improved vaccine adjuvants
Article Abstract:
Adjuvants and delivery systems have become important for the development of new subunit vaccines consisting of isolated antigens because their invasiveness provides efficient delivery to antigen presenting cells and helps in stimulating the innate immune system. Details of the discovery and development of immunostimulatory compounds and vaccine formulations that target innate immune response are discussed.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2005
User Contributions:
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