Carbon monoxide suppresses arteriosclerotic lesions associated with chronic graft rejection and with balloon injury
Article Abstract:
Research indicates a protective role for carbon monoxide in vascular injury by preventing arteriosclerotic lesions occurring following aorta transplantation. Data show pre-exposure to 250 parts per million of carbon monoxide for 1 hour suppresses stenosis by inhibiting graft leukocyte infiltration/activation and smooth muscle cell proliferation.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2003
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Carbon monoxide has anti-inflammatory effects involving the mitogen-activated protein kinase pathway
Article Abstract:
Carbon monoxide may have therapeutic potential as an anti-inflammatory agent. It inhibits the production of inflammatory cytokines in vitro and in vivo and increases the production of the anti-inflammatory cytokine interleukin-10.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 2000
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Requirement for CD154 in the progression of atherosclerosis
Article Abstract:
CD40-CD154 signaling appears to be involved in the progression of atherosclerotic lesions. In mice who were homozygous for a CD154 gene mutation, atherosclerotic plaque area was reduced 550%.
Publication Name: Nature Medicine
Subject: Health
ISSN: 1078-8956
Year: 1999
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