Caspase inhibition reduces apoptosis and increases survival of nigral transplants

Article Abstract:

The authors state that general rejection of fetal brain tissue transplanted to alleviate Parkinson's disease can be reduced. Generally, only 5-10% of the tissue survives, but prevention of apoptosis can improve that percentage and reduce the amount of the severely limited transplant tissue which is needed.

Health aspects, Research, Physiological aspects, Cell death, Parkinson's disease, Parkinson disease, Fetal tissue transplantation

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Chronic brain inflammation and persistent herpes simplex virus 1 thymidine kinase expression in survivors of syngeneic glioma treated by adenovirus-mediated gene therapy: implications for clinical trials

Article Abstract:

Gene therapy for glioblastoma that uses an adenoviral vector may cause inflammation in the brain. This was discovered in patients who received the herpes simplex virus 1 thymidine kinase gene, which suppressed glioma growth but caused inflammation and demyelination.

Care and treatment, Complications and side effects, Gene therapy, Brain, Inflammation, Glioblastoma multiforme

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