Cellular and Anatomical Reservoirs of HIV-1 in Patients Receiving Potent Antiretroviral Combination Therapy
Article Abstract:
Complete eradication of HIV with antiviral medications is hampered by persistence of the virus in cellular and anatomic reservoirs. CD4+ T-cells, macrophages, and other immune cells may contain latent virus despite successful suppression of blood-borne virus by drug therapy. The central nervous system, poorly penetrated by many drugs, may retain sufficient viral load to prevent complete elimination of HIV disease. The testes may also retain infected cells resistant to antiretroviral therapy. Drugs targeted to the elimination of viral reservoirs may be key to eliminating HIV infection.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 1998
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Current Evidence and Future Directions for Targeting HIV Entry: Therapeutic and Prophylactic Strategies
Article Abstract:
Researchers hope to develop AIDS drugs that can prevent the virus from entering cells. This process begins when the viral envelope glycoprotein binds to the CD4 receptor on T cells. The glycoprotein-CD4 complex then binds to chemokine receptors. Finally, the viral membrane fuses with the cell membrane. Any one of these steps could be targeted by drugs that prevent that step. An AIDS vaccine is also urgently needed, because most cases of AIDS occur in developing countries that cannot afford most AIDS drugs.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2000
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Serious Adverse Events Attributed to Nevirapine Regimens for Postexposure Prophylaxis After HIV Exposures--Worldwide, 1997-2000
Article Abstract:
The FDA has received 22 reports of serious adverse reactions to the AIDS drug nevirapine. In some cases, the drug caused liver failure leading to the need for a liver transplant. This drug is often given to healthcare workers who are exposed to the blood of an HIV patient.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2001
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