Cerebrospinal fluid HIV RNA and drug levels with combination ritonavir and saquinavir

Article Abstract:

The authors note that the combination of ritonavir and saquinavir are effective in keeping viral blood count low, but that the blood-brain barrier may keep the drugs from the cerebrospinal fluid (CSF), thereby allowing a safe haven for the HIV virus. Despite many variable factors which further study might clarify, the HIV RNA levels seem equally low in CSF as in blood.

Statistical Data Included, Ritonavir

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Cerebrospinal fluid viral load, intrathecal immunoactivation, and cerebrospinal fluid monocytic cell count in HIV-1 infection

Article Abstract:

The authors examined the proportional relationships between certain types of measurements used in HIV management, such as cerebrospinal fluid (CSF) viral load and others. They found, unexpectedly, that in patients with a CD4 count below 200, there was a direct correlation to the CSF viral load.

CD4 lymphocytes

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High-dose saquinavir plus ritonavir: long-term efficacy in HIV-positive protease inhibitor-experienced patients and predictors of virologic response

Article Abstract:

High-dose saquinavir may be beneficial in HIV patients who have not responded to other protease inhibitors. In a study of 58 such patients, about half achieved very low viral levels while taking the drug. Those with lower viral levels initially were more likely to respond to the drug.

HIV infection, Drug therapy, HIV infections

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