Viral load and disease progression in infants infected with human immunodeficiency virus type 1

Article Abstract:

Infants infected with HIV at birth whose HIV RNA counts are high should receive drugs to prevent the development of AIDS. Researchers periodically measured HIV RNA in blood samples from 106 infants infected with HIV at birth. Blood RNA levels were highest during the first two months of birth and declined thereafter. Levels during the first two months were over three times higher in those infants whose infection subsequently progressed compared to those whose infection did not progress. Less than one-fourth of the mothers had taken zidovudine during pregnancy.

Measurement, Development and progression, HIV (Viruses), HIV, HIV infection in children, Pediatric HIV infections, RNA

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Obstetrical factors and the transmission of human immunodeficiency virus type 1 from mother to child

Article Abstract:

HIV-infected pregnant women whose membranes rupture more than four hours before delivery may have a greater risk of transmitting the virus to their newborn baby. Among 509 HIV-infected women enrolled in the Women and Infants Transmission Study, those whose membranes ruptured more than four hours before delivery had almost twice the risk of transmitting the virus compared to women whose membranes ruptured less than four hours prior to delivery. Illegal drug use also doubled the risk as did low birth weight. A low CD4 count almost tripled the risk.

Premature rupture of membranes, Premature rupture of the membrane

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Maternal levels of plasma human immunodeficiency virus type 1 RNA and the risk of perinatal transmission

Article Abstract:

The risk of HIV transmission from a pregnant, infected woman to her child increases with the maternal viral load. Researchers compared 552 HIV-positive women and their infants for factors influencing viral transmission. For women with viral loads below 1,000 copies/ml, no infant infections occurred. For women with viral loads above 100,000 copies/ml and not taking antiviral drugs, 63% of the resultant children were HIV-infected. Maternal viral load was not associated with the timing of viral transmission during pregnancy.

United States, Statistical Data Included, Viremia

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