Changes in the slope of the CD4 cell count increase after initiation of potent antiretroviral treatment
Article Abstract:
The slopes of CD4 cell count increases over 72 weeks in 101 subjects with frequent CD4 cell count evaluations and successful virologic responses to antiretroviral treatment (ART) were examined to estimate more precisely the time point soon after ART initiation that best delineates this change in the slope of CD4 cell count measurements. The results suggest that analyses should examine CD4 cell count changes from 12 weeks or later after the initiation of potent ART so as to remove the influence of the steep initial slope of the CD4 cell count increase.
Publication Name: Journal of Acquired Immune Deficiency Syndromes (1999)
Subject: Health
ISSN: 1525-4135
Year: 2006
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Biology of CCR5 and its role in HIV infection and treatment
Article Abstract:
The biology of CC chemokine receptor 5 (CCR5) inhibition on host immunity is discussed and the effects that targeting CCR5 have on host defenses are explored in individuals with immunity already compromised by HIV infection. It is observed that through interactions with its chemokine ligands, the chemokine receptor CCR5 helps to initiate immune response and to distribute effector immune cells to sites of inflammation.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
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Predictive value of plasma HIV RNA level on rate of CD4 T-cell decline in untreated HIV infection
Article Abstract:
The proportion of variability is estimated in rate of CD4 cell loss predicted by presenting plasma HIV RNA levels in untreated plasma human immunodeficiency virus (HIV)-infected persons. The HIV RNA levels predict the rate of CD4 cell decline only minimally in untreated persons, which have implications for treatment decisions in HIV infection and for understanding the pathogenesis of progressive immune deficiency.
Publication Name: JAMA, The Journal of the American Medical Association
Subject: Health
ISSN: 0098-7484
Year: 2006
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