Chemoradiotherapy for localized non-Hodgkin's lymphoma

Article Abstract:

Fewer cycles of chemotherapy plus radiation therapy appears to be more beneficial in the treatment of non-Hodgkin's lymphoma than chemotherapy alone. A 1998 study found that disease-free and overall survival rates were higher in lymphoma patients who received three cycles of chemotherapy and radiation compared to patients who received eight cycles of chemotherapy. Fewer chemotherapy cycles led to a reduction in toxic effects of the treatment. It could also reduce the risk of a second tumor, which can be caused by some chemotherapy drugs.

Editorial

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Chemotherapy alone compared with chemotherapy plus radiotherapy for localized intermediate- and high-grade non-Hodgkin's lymphoma

Article Abstract:

Three cycles of chemotherapy plus radiation treatment appears to be superior to chemotherapy alone in the treatment of non-Hodgkin's lymphoma. Researchers randomly assigned 401 patients with non-Hodgkin's lymphoma to receive eight cycles of cyclophosphamide, doxorubicin, vincristine and prednisone (CHOP) or three cycles of CHOP plus radiation treatment. Five-year disease-free and overall survival rates were higher in the patients who received CHOP plus radiation. Fewer patients in this group had a toxic reaction to treatment.

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Prediction of survival in follicular lymphoma based on molecular features of tumor-infiltrating immune cells

Article Abstract:

The patients with follicular lymphoma survival are determined to be for periods less than 1 year to more than 20 years after diagnosis. The gene-expression profiles of tumor-biopsy specimens obtained at diagnosis are used to develop a molecular predictor of the length of survival. It is found that the length of survival among patients with follicular lymphoma correlates with the molecular features of nonmalignant immune cells present in the tumor at diagnosis.

Science & research, England, Research, Patient outcomes, Diagnosis, Patients, Lymphomas

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